血脑屏障通透性增效方法的研究进展.pdf

化学通报 2015 年 第 78 卷 w2015010 进展评述 血脑屏障通透性增效方法的研究进展 梁 静 刘 军 贺全国* (湖南工业大学绿色包装与生物纳米技术应用湖南省重点实验室 株洲 412007) 摘 要 血脑屏障作为脑部的屏障系统，具有较强的保护作用，维持着中枢神经系统的内环境的稳定， 同时也阻止药物进入脑部治疗中枢神经系统疾病。多年来，在提高血脑屏障通透性的研究方面有了很大进展， 让药物靶向入脑，为治疗中枢神经系统疾病提供了很大的帮助。本文系统介绍血脑屏障的结构，其中主要介绍 产生血脑屏障的解剖和功能结构，并对提高其通透性的增效方法和机制进行了概括，主要从物理、化学、生物 学和纳米给药载体等方面阐述了提高血脑屏障透过方式，并简要介绍了一些具体药物的输送的应用。 关键词 血脑屏障 脑部给药 中枢神经系统 疾病 Research Progress in Methods of Improving Blood Brain Barrier Permeability Liang Jing, Liu Jun, He Quanguo* (Key Laboratory of Green Packaging and Application Biological Nanotechnology of Hunan Province, Hunan University of Technology, Zhuzhou 412007) Abreact The Blood Brain Barrier (BBB) as a brain barrier system is crucial in protecting the brain and is essential for maintaining their bathing microenvironment. This makes it difficult to deliver beneficial drugs across the BBB to treat Central Nervous System (CNS) diseases. Great progress has been made in research efforts in improving the BBB permeability in recent years, thus providing a lot of help to delivery drug to the targeted brain part and to treat CNS diseases. This paper discusses the anatomical and functional structures of the BBB and summarizes the methods and mechanisms of increasing BBB permeability comprehensively. It also elaborates on the physics, chemistry, biology and nanocarrier aspects to improve drug delivery to the brain, and introduces some specific drug delivery. Keywords Blood brain barrier, Drug delivery system to brain, Central nervous system, Diseases 血脑屏障(BBB)是机体最重要的屏障之一。它是由毛细血管内皮细胞形成的血液与脑组织间的屏障。 BBB 不仅可以阻止有害的物质进入脑内，还可以选择性地将有害物质或过剩物质泵出脑外，为脑组织提 供了一个相对