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RESEARCH ◥ acetylated histone H3 Lys27 (a lysine targeted RESEARCH ARTICLE SUMMARY by CBP) near CBP binding sites. Although un- treated majors rarely foraged, suppression of histone deacetylation by injection of HDACi or BEHAVIORAL GENETICS ◥ small interfering RNAs ON OUR WEB SITE (siRNAs) against the HDAC- Epigenetic (re)programming of Read the full article encoding gene Rpd3 into at http://dx.doi. young major brains was suf- org/10.1126/ ficient to induce and sustain caste-specific behavior in the ant science.aac6633 minor-like foraging and scouting for up to 50 days. Camponotus floridanus