北京女性尿液中双酚A及氯代双酚A的浓度和风险评价.pdf

中国环境科学 2015,35(9) ：2853~2860 China Environmental Science 北京女性尿液中双酚 A 及氯代双酚 A 的浓度和风险评价 陈 默,范湛蓝,高 群,高福梅,牟 迪,胡建英* (北京大学城市与环境学院,地表过程分析与模拟教育部重点 实验室,北京 100871) 摘要：建立了有机相丹酰化衍生-UPLC-MS-MS 人体尿液样品中双酚 A(BPA)及 4 种氯代双酚 A(氯代 BPA) 的检测方法,对北京地区 40 个 女性尿液样品进行了检测.结果表明:BPA 和一氯、二氯、三氯、四氯 BPA 的检出率分别为 90%、96%、90%、52%和 45%;浓度分别为 (1.30±1.24),(0.40±0.37),(0.41±0.51),(0.18±1.49),(0.46±0.35) ng/mL,4 种氯代 BPA 的总浓度为 1.45ng/mL,和 BPA 浓度相仿.4 种氯代 BPA 的 BPA 等当量浓度为 4.84ng/mL,是 BPA 浓度的 2.2 倍. 40 个尿液样本 BPA 等当量浓度符合对数正态分布,超过 BPA 的糖尿病发生阈值(0.05% 发病风险)5.7ng/mL 的概率为 19.2%.人体暴露氯代 BPA 的健康风险应该引起重视. 关键词：氯代双酚 A ；丹酰化衍生；摄入量；等当量；LC-MS-MS 中图分类号：X503.1 文献标识码：A 文章编号：1000-6923(2015)09-2853-08 Levels and risk assessment of bisphenol A and chlorinated BPAs in urine samples of Beijing women. CHEN Mo, * FAN Zhan-lan, GAO Qun, GAO Fu-mei, MU Di, HU Jian-ying (College of Urban and Environmental Sciences, Peking University, Beijing 100871, China). China Environmental Science, 2015,35(9)：2853~2860 Abstract ：A derivatization UPLC-MS-MS method was used to analyze bisphenol A (BPA) and its chlorinated derivatives, including monochloro-BPA, dichloro-BPA, tricholro-BPA, and tetrachloro-BPA, in 40urine samples of Beijing women. The detection frequencies of BPA, monochloro-BPA, dichloro-BPA, tricholro-BPA, and tetrachloro-BPA were 90%, 96%, 90%, 52%, and 45% with average concentrations of (1.30±1.24), (0.40±0.37), (0.41±0.51), (0.18±1.49), (0.46±0.35) ng/mL, respectively. While the total concentration of four chlorinated BPA was 1.45ng/mL, which was similar with that of BPA in urine, their BPA toxic equivalent quantity (TEQBaP) in urine was calculated to be 4.84ng/mL, which was 2.2 fold higher than that of BPA. The TEQBPA concentration was log-normally distributed, and the probability higher than Benchmark D