抗HIV感染治疗模型及临床数据模拟.pdf

8 2015 ，51（5 ） Computer Engineering and Applications 计算机工程与应用 抗HIV 感染治疗模型及临床数据模拟 1 1，2 孙起麟 ，闵乐泉 1 1，2 SUN Qilin , MIN Lequan 1.北京科技大学 自动化学院，北京 100083 2.北京科技大学 数理学院，北京 100083 1.School of Automation and Electrical Engineering, University of Science and Technology Beijing, Beijing 100083, China 2.School of Mathematics and Physics, University of Science and Technology Beijing, Beijing 100083, China SUN Qilin, MIN Lequan. Anti-HIV infection treatment model and clinical data simulation. Computer Engineering and Applications, 2015, 51 （5 ）：8-13. Abstract ：Based on a saturated infection rate and the mechanism of Human Immunodeficiency Virus （HIV ）inducing the apoptosis in CD4 + T cells, a modified anti-HIV infection treatment model is proposed. This model has an infection-free equilibrium point and an endemic infection equilibrium point. It shows that if the model ’s basic reproductive number R 0 less than 1, then the infection-free equilibrium point of the model is globally asymptotically stable, if the model ’s R 0 greater than 1, then the endemic infection equilibrium point of the model is locally asymptotically stable. Based on the clinical data from HIV drug resistance database of Stanford University, it uses the proposed model to simulate the dynamics of a group patients ’anti-HIV infection treatment and make long-term prediction for the group ’s anti-HIV infection treat- ment. Numerical simulations suggest that the anti-HIV infection treatment cannot control HIV inducing the apoptosis of CD4+ T cells, when the drug resistance appears, the resistance may get stronger if nothing changes in anti-HIV infection treatment, the anti-HIV infection treatment of the group patients is failed eventually. Key words ：Human Immunodef