高分子材料与应用(双语)-Smart Hydrogel3.pptVIP

Chapter 6 Functional Polymers 6.8 Smart Hydrogel Xie Xingyi, Ph. D College Polymer Sci. Eng., Sichuan University 1. Introduction Gels cross-linked polymer networks that can absorb enough solvent to swell. Hydrogels hydrophilic polymer networks which swell in water. 1. Introduction 1. Introduction Smart Hydrogels undergo strong conformational changes when only small changes in the environment occur. 1. Introduction Volume phase transition Chemical gels: abruptly swell to many times its original size--or collapse into a compact mass with a small change in solvent concentration or temperature Sol-gel transition A physical gel: often change from a solution state to a gelation state (above CGC at LCST) with a small change of temperature or concentration Volume phase transition Glucose Sensitive Hydrogel Sol-gel transition Phase diagram of a PEG–PLGA–PEG (550–2810–550). 2. History of Smart Hydrogel 1975, Toyoichi Tanaka discovered smart hydrogel ionized gels immersed in water-acetone solutions : volume dramatically changed. First commercial product in 1994 GelMed liquid at room T; viscous at body T at 1 to 3%. 3. Classification and property Classified based on the type of stimuli. The physical stimuli temperature, electric fields, composition, light, pressure, sound and magnetic fields Chemical or biochemical stimuli pH, ions and specific molecular recognition events. 3.1 Temperature-sensitive Hydrogels Structure: possess moderately hydrophobic groups (Chemical Hydrogel) Structure: hydrophilic hydrophobic segments (physical Hydrogel) Properties At lower temperature hydrogen bonding between hydrophilic segments of the polymer chain dominates – swelling or solution state At higher temperature hydrophobic interactions among hydrophobic segments become strengthened, while hydrogen bonding becomes weaker – shrinking or gelation occur 3.2 pH-sensitive Hydrogels Properties of pH-sensitive H