蛋白质的生物合成分子生物学.pptxVIP

;;;蛋白质合成的起始是指:;;? The ribosome must be recruited to the mRNA; ? A charged tRNA must be placed into the P site of the ribosome; ? The ribosome must be precisely positioned over the start codon (This is critical).;真核生物: ? 40 S小亚基首先与Met-tRNAMet相结合， ? 再与模板mRNA结合， ? 最后与60S大亚基结合生成 80S·mRNA·Met-tRNAMet起始复合物。;;A specialized tRNA (initiator tRNA) charged with a modified methionine (f-Met) binds directly to the prokaryotic small subunit;A special initiator tRNA starts the;A model of initiation factor binding to;;细菌翻译的起始;?Met-tRNA;The 5