解读与雾化吸入激素在AECOPD中应用.pptVIP

PERMISSION TO ADAPT TABLE TO BE REQUESTED UPON APPROVAL A total of 121 patients completed the study (BD only, n=39; BD + PRED, n=40; BD + BUD, n=42).Gunen et al 2007/4/4 The percentages of patients with relatively early and delayed discharge were not significantly different among the groups.Gunen et al 2007/6/4 Percentages of patients discharged at day 10 were 54%, 50%, and 45% for the BD only, BD + PRED, and BD + BUD groups, respectively.Gunen et al 2007/6/4 Discharge was delayed (15 days) in 10%, 10%, and 7% in the BD only, BD + PRED, and BD + BUD groups, respectively.Gunen et al 2007/6/4 There was a trend toward a significant difference in favor of the corticosteroid groups for exacerbations and re-hospitalization 1 month after discharge, but there were no significant differences across treatments.Gunen et al 2007/7/1 Within 1 month of discharge, there were 14, 8, and 9 exacerbations in the BD only, BD + PRED, and BD + BUD groups, respectively.Gunen et al 2007/6/5 These exacerbations resulted in 8, 4, and 5 hospitalizations in the BD only, BD + PRED, and BD + BUD groups, respectively, during the month after discharge.Gunen et al 2007/7/1 Gunen H, Hacievliyagil SS, Yetkin O, Gulbas G, Mutlu LC, In E. The role of nebulized budesonide in the treatment of exacerbations of COPD. Eur Respir J. 2007. Insert full citation when in print With regard to the absolute values of arterial blood gases and spirometric measurements at 10 days, mean forced expiratory flow between 25 and 75% of FVC (FEF25–75%) value in group 3 was significantly higher than the values in group 1 and 2 (p50.03 and p50.027 respectively). In addition to this, while direct comparison of arterial blood gases and spirometric parameters did not reveal any difference between group 1 and 2, FEV1 was also found to be significantly higher in group 3 than in group 1 (p＝0.004). 糖皮质激素抗炎作用有基因和非基因两个途径。基因途径主要是通过细胞质受体所介导，包括与DNA直接结合（A）或转录因子失活（B）导 致使转录发生改变。相反，非基因途径主要包括与细胞膜受体结合（C）或者与细胞质受体结合（D）以及与细胞膜非特异性相互作用（E），产生快速反应。