缺血性卒中二级预防中抗血小板治疗策略方案.pptVIP

大出血事件 ? 复发卒中和颅内出血 Sacco RL, Diener HC, Yusuf S, et al. Aspirin and extended-release dipyridamole versus clopidogrel for recurrent stroke. N Engl J Med, 2008,359:1238-51 ? 不良事件 ASA+ER-DP Clopidogrel 随机患者人数 10181 10151 不能连续用药的头痛 600 (5.9%) 88 (0.9%) 头晕或头轻 1365 (13.6%) 908 (9.1%) 晕厥 149 (1.5%) 76 (0.8%) 6个月内偏头痛 562 (5.9%) 314 (3.3%) Note: Slides reproduced accurately based on data orally presented. Not validated with a published source. R Sacco. Presented at ESCo 2008. ? 研究结论 ASA+ER-DP 和波立维 预防卒中复发和主要血管事件相似 大出血事件（包括颅内出血）在 ASA+ER-DP 组更多(42%) 在 ASA+ER-DP 组因头痛而停药者（593例，5.9%）约为波立维组（87例，0.9%）的6倍 ?