88例卵巢上皮性癌行ATP-TCA体外药敏试验结果分析.PDF

中国细胞生物学学报 Chinese Journal of Cell Biology 2014, 36(7): 989–993 DOI: 10.11844/cjcb.2014.07.0124 88例卵巢上皮性癌行ATP-TCA 体外药敏试验结果分析 * 崔 颖 周 丹 李 叶 申桂华 张斯由 (北京医院妇产科, 北京 100730) 报 摘要 该研究是探讨三磷酸腺苷生物荧光肿瘤抗癌药物药敏性分析实验(ATP-TCA)在卵巢 癌患者化疗中的应用。研究选取88例卵巢上皮性癌新鲜组织行ATP-TCA体外药敏试验, 分析结果、 计算各种化疗药物敏感性, 并与48例对照组患者进行临床近期有效率的比较。结果显示, 在体外药 敏试验敏感性最强的单药为紫杉醇(51.9%), 敏感性强弱依次为: 紫杉醇卡铂顺铂 吉西他滨拓 学 泊替康多西他赛依托泊苷环磷酰胺博来霉素, 联合用药方案敏感性较单药增加。药敏组患者 临床近期有效率(85.23%) 高于对照(68.75%)。ATP-TCA是一种有效的抗癌药物敏感性分析实验, 可 为卵巢癌患者临床化疗提供个体化的指导方案。 关键词 原发卵巢上皮性癌; ATP-TCA; 个体化治疗 学 Analysis Results of ATP-Tumor Chemosensitivity Assay In Vitro of 88 Cases of Epithelial Ovarian Cancer 物 Cui Ying*, Zhou Dan, Li Ye, Shen Guihua, Zhang Siyou (Department of Obstetrics and Gynecology, Beijing Hospital, Beijing 100730, China) 生 Abstract In this research, we demonstrated the feasibility of ovarian cancer patients in clinical individual- ized chemotherapy using ATP-tumor chemosensitivity assay (ATP-TCA) in vitro. We examined the heterogeneity of chemosensitivity in ovarian cancer specimens (n=88) using an ex vivo ATP-TCA. The short-term effectiveness of chemotherapy was compared between ATP group and control group. We found that the most active single agent 胞 tested was paclitaxel, to which 51.9% of samples were sensitive. The order of the sensitivity is paclitaxel carbo- platin cisplatin gemcitabine topotecan docetaxel etoposide cyclophosphamide bleomycin. Combina- tions of agents showed more strong sensitivity cases. The short-term effectiveness rates in A