毛囊干细胞的迁移性.docVIP

European Journal of Cell Biology 86(2007355–376 Hair follicle stem cells:Walking the maze Stephan Tiede a ,Jennifer E.Kloepper a,b ,Eniko Bodo a ,Sanjay Tiwari c ,Charli Kruse d ,Ralf Paus a,? a Department of Dermatology,University Hospital Schleswig-Holstein,University of Lu ¨beck,Ratzeburger Allee 160,D-23538Lu ¨beck,Germany b Department of Molecular Medicine,Max-Planck-Institute for Biochemistry,Martinsried,Germany c Department of Surgery,Molecular Oncology Section,University Hospital Schleswig-Holstein,University of Kiel,Kiel,Germany d Fraunhofer-Institute of Biomedical Engineering,Group of Cell Differentiation and Cell Technology at the University of Lu ¨beck,Lu ¨beck,Germany Received 11December 2006;received in revised form 20March 2007;accepted 21March 2007 Abstract The discovery of epithelial stem cells (eSCsin the bulge region of the outer root sheath of hair follicles in mice and man has encouraged research into utilizing the hair follicle as a therapeutic source of stem cells (SCsfor regenerative medicine,and has called attention to the hair follicle as a highly instructive model system for SC biology.Under physiological circumstances,bulge eSCs serve as cell pool for the cyclic regeneration of the anagen hair bulb,while they can also regenerate the sebaceous gland and the epidermis after injury.More recently,melanocyte SCs,nestin +,mesenchymal and additional,as yet ill-de?ned ‘‘stem cell’’populations,have also been identi?ed in or immediately adjacent to the hair follicle epithelium,including in the specialized hair follicle mesenchyme (connective tissue sheath,which is crucial to wound healing.Thus the hair follicle and its adjacent tissue environment contain unipotent,multipotent,and possibly even pluripotent SC populations of different developmental origin.It provides an ideal model system for the study of central issues in SC biology such as plasticity and SC niches,and for the identi?cation of reliable,speci?c SC markers,which distinguish them fro