钙与信号传导.ppt

L-type Ca2+ channel PKA phosphorylation Regulation of L-type Ca2+ channels : Increases in: number probability open time * PPT课件 2. Internal Ca2+ release from ER/SR 内质网/肌浆网 Ryanodine receptor (2) IP3 receptor * PPT课件 (1) Ryanodine receptor (RyR): mediates the efflux of Ca2+ from the SR and plays a central role in excitation-contraction (E-C) coupling. 特点 1.所需钙阈值较低 1.5-2.0μM,咖啡因可降低此阈值,Mg可升高此阈值; 2.全或无的释放 为CICR正反馈介导 * PPT课件 Mechanisms of E-C coupling * PPT课件 Isoforms of RyR RyR1: Skeletal muscle RyR2: Cardiac muscle RyR3: Brain (Coronado, 1994) DHP