讲真核基因表达调控 .ppt

Regulation of Termination of RNA Pol II The transcript is extended beyond the site where the poly(A) tail is to be added, then is cleaved at the poly(A) addition site by an endonuclease component of a large enzyme complex, again associated with the CTD of RNA polymerase II. Some viral genes and stress response genes can be regulated by resisting termination. 1. The termination regulation of HIV genes. A termination-resisting protein, Tat, is usually involved in HIV gene expression in infectious cells. 2. The termination regulation of heat shock protein genes. Heat shock transcription fact