TregTh17平衡失调在复发性流产中的作用.PDFVIP

中国细胞生物学学报 Chinese Journal of Cell Biology 2016, 38(3): 322–328 DOI: 10.11844/cj cb.2016.03.02 18 Treg/Th17平衡失调在复发性流产中的作用 成 雁1* 郭红玲1 滕银成2 1 2 ( 苏州大学附属太仓市第一人民医院, 苏州2 15400; 上海交通大学附属第六人民医院, 上海200233) 摘要 正常妊娠被认为是一种成功的半同种移植, 有赖于母胎界面生理性抑制反应的增强, 称为免疫耐受。孕妇的免疫系统失调可以导致生殖失败, 同种免疫的异常很有可能是复发性流产 的发病机理。随着对免疫耐受机制研究的不断深入, 母胎免疫耐受的研究从Th 1/Th2细胞平衡失调 进一步发展到对Treg/Th 17细胞平衡失调的研究, 该文综述了Treg/Th 17细胞平衡失调在原因不明复 发性流产中的作用。 关键词 流产; 复发性; 调节性; Th 17细胞 The Role of Treg/Th17 Imbalance in the Recurrent Spontaneous Abortion Cheng Yan1*, Guo Hongling1, Teng Yincheng2 1 2 ( Department of Gynecology, the First People’s Hospital of Taicang, Taicang 215400, China ; Department of Obstetrics and Gynecology, Sixth Affiliated Hospital of Shanghai Jiaotong University, Shanghai 200233, China) Abstract The human gestation is considered to be a successful semi-allograft, which depends on the enhancement of physiologic inhibition response in maternal-fetal interface, called immune tolerance. The imbalance of pregnant women immune system leads to reproductive failure, and the abnormal homologous immunization could be most likely the pathogenesis of recurrent spontaneous abortion (RSA). Mechanisms of immune tolerance are in the deepening, from the Th1/Th2 balance to the Treg/Th17 balance. In this paper, the role of Treg/Th17 imbalance in RSA is reviewed. Keywords abortion; recurrent; regulatory; Th17 cells 复发性流产(recurrent spontaneous abortion, RSA) 早在1991年, Th1/Th2细胞的假说已被提出, 此后 是指连续自然流产2次或2次以上, 散发的流产通常 的研究认为, 精确的Th 1/Th2细胞因子的平衡是维持 存在胚胎畸形或染色体异常, 而复发性流产大多数