《环蕃化学》-公开课件.pptVIP

At high concentration polymerization reactions dominate. The probability of a molecule meeting a second molecule decreases as the concentration decreases; therefore, the more dilute the solution, the better the ratio of macrocycle to polymer. The high dilution method is used in the synthesis of macrocyclic compounds. Typical high dilution reactions involve milligrams or tens of milligrams of reactants in solvent volumes of the order of litres. In a typical high dilution synthesis, solutions of each component are slowly added dropwise to a large volume of solvent, keeping the concentration of the intermediate low. High dilution techniques: 4.2 四氮杂环蕃化合物的修饰 二茂铁磺酰基四氮杂对环蕃的合成 环蕃仿酶体系中引进了二茂铁磺酰基，通过对环蕃化合物的修饰，实现其对底物的多部位包结和多重识别，更好地模拟酶的识别和催化功能，提供高效率和高选择性的桥联环蕃模拟酶新模型。 The synthesis of ferrocenesulfonyl tetraazacyclophanes 4.3 桥联四氮杂环蕃的合成 Shi Zhen, Synthetic Communications, 1997, 27 (13): 2235～2239 Synthesis of dibridged macrocyclic tetraazacyclophanes 具有网状桥联结构的四氮杂环蕃化合物 Shi Zhen, 2nd International Symposium on Macrocyclic Ligands for the Design of New Materials, Argentina, 1994,8. 29-9.1 新型桥联仿酶环蕃化合物的合成 Synthesis of new bridged tetraazacyclophanes 桥联仿酶环蕃化合物的合成路线 桥联仿酶环蕃化合物的合成路线 4.4 立方形环蕃 的合成 Urushigawa,T.I.,Yoshino,T., Bull.Chem.Soc. Jpn., 1971,44: 2546 第五节 四氮杂环蕃酶催化作用的模拟 水溶性四氮杂环蕃分子中的两个苯环和亚甲基可以形成疏水的空腔. 5.1 四氮杂环蕃的包合作用 酶催化反应具有极高的效率和高度的选择性。酶催化作用的模拟，是一个富有挑战性的研究领域，激发着化学家尤其是生物有机化学家浓厚的兴趣。 Computer-optimized structure of the cyclophane(CP66) Computer-optimized structure of the cyclophane(CP66) and most probable inclusion complex geometry(B), (C) with naphthalene as representative substrate for pseudoequatorial inclusion. CP44的均四甲苯包结物的晶体结构 Cyclophane binds apolar guests such as 1,2,4,5-tetramethylbenzene (durene) The first example of inclution within a cyclophane cavity was obtained by Koga and co-workers. Durene was deeply included within the cyclophane cavity. Binding studies were carried out in acidic aqueous solution. 四甲