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- 2020-03-07 发布于上海
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合作课题与NIH申请书的书写;合作课题申请:;Significance: The CIPRA cohort offers a unique population infected at about the same time with a uniform HIV strain. Determining immunologic parameters that differentiate progression of disease from non-progression can be quite significant.;Investigators: The PI, Dr. Xu, is experienced in HIV immunology research. His research team has relevant experience in biostatistics and molecular virology; however, the responsibilities of each team member are not described. ;Innovation: The study of CD8 responses to specific viral epitopes and correlation with Treg function in progressor vs. non-progressor populations is innovative.;Investigators: The PI, Dr. Xu, is experienced in HIV immunology research. His research team has relevant experience in biostatistics and molecular virology; however, the responsibilities of each team member are not described. ;THE FOLLOWING RESUME SECTIONS WERE PREPARED BY THE SCIENTIFIC REVIEW ADMINISTRATOR TO SUMMARIZE THE OUTCOME OF DISCUSSIONS OF THE REVIEW COMMITTEE ON THE FOLLOWING ISSUES:
PROTECTION OF HUMAN SUBJECTS (Resume): ACCEPTABLE (30). Informed consent seems adequate; privacy protection is in place; options for treatment are well defined. However, the study procedures and potential risks are not described. The text should also address plans to “collect additional blood if necessary”.
INCLUSION OF WOMEN PLAN (Resume): ACCEPTABLE (G1A). However, the specifics related to recruitment of women are lacking.
INCLUSION OF MINORITIES PLAN (Resume): ACCEPTABLE (M5A). However, the specifics related to recruitment of minorities are lacking.
INCLUSION OF CHILDREN PLAN (Resume): ACCEPTABLE (C1A).
BIOHAZARD COMMENT: Protection against blood-borne pathogens should be addressed.
FOREIGN INSTITUTION: The proposed project utilizes a unique subject cohort at the foreign location, and supports the activities of local researchers
COMMITTEE BUDGET RECOMMENDATIONS: The budget was recommended as requested.;基本原则:;Significance: The signi
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