第三章CC双键形成.pptxVIP

Chapter 3 Formation of Carbon-Carbon Doule BondsI. The Synthetic Methods of Alklenes 1. ?-Elemination reactions （?-消去反应）2. Pyrolytic syn eliminations（顺式热消去反应）Applications: Synthesis of terminal alkenes from primary acetatesDisadvantages: High reaction temperatureChugave reactionCope reaction反应条件比对应的酯热消去温和。3. Wittig and related reactions （Wittig 及有关反应） Wittig Reaction G. Wittig received the 1979 Nobel Prize in Chemistry for many significant contributions to Organic Chemistry which included not only the Wittig reaction, but also PhLi prepared by metal- halogen exchange, benzyne, and the Witti