盐酸曲马多片剂人体药代动力学和相对生物利用度研究.docVIP

PAGE / NUMPAGESPAGE / NUMPAGES 盐酸曲马多片人体药代动力学和生物等效性的研究 药学（） 【关键词】 盐酸曲马多　　Pharmacokinetics and relative bioequivalence of tramadol hydrochloride in healthy volunteers　　【Abstract】 AIM: To compare the pharmacokinetic parameters and relative bioavailability of domestic and imported tramadol hydrochloride tablets so as to ensure quality of the medicine. METHODS: An open, randomized, two period crossover study with a two week washout interval was performed in 18 healthy volunteers. Concentrations of tramadol in serum were assayed by HPLC FR method. The pharmacokinetics parameters, AUC, Cmax and