细胞凋亡和细胞自噬最新版本.ppt

史 娟 医科院基础所 新科研楼607 E-mail: shijuantt@;.;Outline;第一节 凋亡的研究历史;1980 Wyllie Biochemical changes in apoptotic morphology: - DNA fragmentation -Requires expression of death genes 1988 Bcl-2 was found to be anti-apoptotic 1991 ced genes were identified in C. elegan 1992 Fas/APO-1/CD95 was identified 1993 A role of p53 in regulation of apoptosis was described Fas ligand was identified ICE was found to be homolog of ced-3 in mammalian IAPs were identified 1994 The role of mitochondria du