HISTOCOMPATIBILITYCOMPLEX(主要组织相容性复合体).pptxVIP

CHAPTER 11THE MAJOR HISTOCOMPATIBILITY COMPLEX;Introduction ;Three classes of MHC genes closely linked on chromosome ClassⅠgene ClassⅡgene ClassⅢgene;Mouse H-2 complex: ClassⅠgene: K, DL class Ⅰmolecules (αchain） ClassⅡgene: I class Ⅱmolecules (αβchain) ClassⅢgene: S complement, TNF;Human HLA complex: ;Genetics of MHC;Polygenic Polymorphic ;Haplotype inherited Codominant;;HLA-Ⅰmolecules ;Structure Two polypeptide chain: H-chain and β2-microglobulin (not coded by the MHC) Heavy chain has 3 domains:α1,α2,α3. Heavy chain α1andα2 domains form the binding groove (t