因耐受性差换用抗精神病药物的推荐-The-Maudsley-Prescribing-Guidelines-10ed.ppt

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因耐受性差换用抗精神病药物的推荐-The-Maudsley-Prescribing-Guidelines-10ed.ppt

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* * 因耐受性差换用抗精神病药物的推荐 Maudsley处方指南第10版换药原因首选药物备选药物急性EPS 阿立哌唑奥氮平喹硫平氯氮平利培酮（6mg/d）齐拉西酮 1. Stanniland C, et al. Tolerability of atypical antipsychotics. Drug Saf 2000; 22:195–214. 2. Tarsy D. et al. Effects of newer antipsychotics on extrapyramidal function. CNS Drugs 2002; 16:23–45. 3. Caroff SN ,et al. Movement disorders associated with atypical antipsychotic drugs. J Clin Psychiatry 2002;63 Suppl 4:12–19. 4. Lemmens P, et al. A combined analysis of double-blind studies with risperidone vs. placebo and other antipsychotic agents: factors associated with extrapyramidal symptoms. Acta Psychiatr Scand 1999; 99:160–170. 5. Taylor DM. Aripiprazole: a review of its pharmacology and clinical use. Int J Clin Pract 2003; 57:49–54.. 耐受性差的换药推荐换药原因首选药物备选药物血脂异常阿立哌唑氨磺必利齐拉西酮 1. Rettenbacher MA ,et al. Early changes of plasma lipids during treatment with atypical antipsychotics. Int Clin Psychopharmacol 2006; 21:369–372. 2. Ball MP, et al. Clozapine-induced hyperlipidemia resolved after switch to aripiprazole therapy. Ann Pharmacother 2005; 39:1570–1572. 3. Chrzanowski WK, et al. Effectiveness of long-term aripiprazole therapy in patients with acutely relapsing or chronic, stable schizophrenia: a 52-week, open-label comparison with olanzapine. Psychopharmacology 2006; 189:259–266. 4. De Hert M, et al. A case series: evaluation of the metabolic safety of aripiprazole. Schizophr Bull 2007; 33:823–830.. 耐受性差的换药推荐换药原因首选药物备选药物糖耐量受损阿立哌唑氨磺必利齐拉西酮利培酮 1. Haddad PM. Antipsychotics and diabetes: review of non-prospective data. Br J Psychiatry Suppl 2004; 47:S80–S86. 2. Berry S, et al. Improvement of insulin indices after switch from olanzapine to risperidone. Eur Neuropsychopharmacol 2002; 12:316. 3. Gianfrancesco FD, et al. Differential effects of risperidone, olanzapine, clozapine, and conventional antipsychotics on type 2 diabetes: findings from a large health plan database. J Clin Psychiatry 2002; 63:920–930. 4. Mir S, et al. Atypical antipsychotics and hyperg