本科生 移植 大课.ppt

慢性排斥(Chronic rejection)－慢性失功(Chronic dysfunction) 发生率：10－20％。每年由于移植物慢性失功造成的移植肝丢失约2000例 发生时间：移植后几个月 病理特征：胆管消失 + 闭塞性动脉内膜炎 分子学检测：移植肝内TGF-β、IL-1β和caspase-1表达增高 治疗：现有免疫制剂无效，再次肝移植 胆管消失综合征 进行性肝内小胆管破坏，肝动脉二、三级分子血管内膜及内膜下泡沫样巨噬细胞进行性浸润，导致阻塞性动脉炎→小叶间胆管缺血坏死。 移植肝慢性失功 FIG. 3. (A) The late stage of CR in the perivenular areas is characterized by severe (bridging) perivenular fibrosis with at least focal central to-central or central-to-portal bridging. (B) Higher magnification of the portal tract showing loss of bile ducts, which affected virtually all of the portal tracts in this biopsy. (C) Higher