ldl c目标值与调脂策略杨国君课件.pptVIP

ldl-c 目标值与调脂策略 _ 杨国君 LDL-C 致病假说 Adapted from Fan J, Watanabe T. J Atheroscler Thromb. 2003;10:63 – 71. Monocyte Induction of adhesion molecules and chemotaxis Adhesion VCAM-1 ICAM-1 P-selectin E-selectin Migration MCP-1 CCR-2 oxLDL oxidation Cytokines MMPs Endothelin-1 Endothelial cells I n t i m a L u m e n CD36 SR-A Differentiation (GM-CSF) Macrophage Foam cell T lymphocyte CD40 IFN-gamma LDL, β -VLDL, Lp(a) ATP III LDL-C 目标值与药物治疗切点 危险分层 LDL-C 目标值 启用 TLC 考虑药物治疗 高度危险 100mg/dL