BNP水平及CPIS与老年重症肺炎患者预后的关系研究.docVIP

BNP水平及CPIS与老年重症肺炎患者预后的关系研究 石先琴1，彭方霖2，柯正华3 湖北省阳新县人民医院呼吸内科1药剂科2，湖北阳新，435200 湖北省黄石市中心医院呼吸内科3，湖北黄石，435000 作者简介：石先琴（1973-11），女，湖北阳新，本科，中级，研究方向：呼吸内科临床，联系手机通讯地址：湖北省阳新县人民医院呼吸内科。 通讯作者：彭方霖（1975-07），男，本科，副主任药师，邮箱： 1611649426@。 黄石市科学技术局 编号：黄科技发农【2015】3号 [摘要]目的：探讨BNP水平及CPIS评分与老年重症肺炎患者预后的相关性。方法 回顾性分析2014年3月-2016年5月在我院接受治疗的老年重症肺炎患者的临床资料，根据其预后分为好转组和恶化组，观察两组患者血清BNP水平、CPIS评分和炎症细胞因子水平的差异，分析BNP水平、CPIS评分、炎症细胞因子水平和肺功能的相关性。结果 好转组患者的BNP水平和CPIS评分均低于恶化组（t=-11.384、-14.916，P0.001）；好转组患者血清降钙素原（PCT）、白介素-18（IL-18）、白介素-6（IL-6）和超敏反应C蛋白（hs-CRP）水平低于恶化组（t=-20.799、-10.734、-11.458、-5.537，P0.001）；好转组患者FVC、FEV1、FEV1/FVC、MMEF和PEF水平明显高于恶化组（t=3.288、6.405、6.640、8.194、5.282，P0.001）；老年重症肺炎患者BNP水平、CPIS评分与PCT、IL-18、IL-6和hs-CRP水平正相关，与FVC、FEV1、FEV1/FVC、MMEF和PEF水平负相关。结论 BNP与CPIS水平与老年重症肺炎患者的肺功能和炎症因子水平相关，且与其预后情况密切相关，可作为判断患者预后的指标。 [关键词] 脑钠肽；肺炎；CPIS；炎症因子；肺功能 Study on the correlation between BNP level and CPIS and prognosis of elderly patients with severe pneumonia Abstract: Objective To investigate the correlation between BINP level and CPIS score and prognosis of elderly patients with severe pneumonia. Methods The clinical data of elderly patients with severe pneumonia treated in our hospital from March 2014 to May 2016 were retrospectively analyzed, According to the prognosis, the patients were divided into Improvement group and deterioration group. The levels of serum BNP, CPIS score and inflammatory cytokines were observed in two groups. The correlation between BNP level, CPIS score, inflammatory cytokines and lung function were analyzed. Results The BNP level and CPIS score of the patients in the improvement group were lower than those in the deteriorated group (t=-11.384, -14.916, P0.001); The serum levels of PCT, IL-18, IL-6 and hs-CRP in the improvement group were lower than those in the deteriorated group (t=-20.799, -10.734, -11.458, -5.537, P0.001); The levels of FVC, FEV1, FEV1/FVC, MMEF and PEF in the improvement group were significantly higher than those in the deteriorated group (t=3.288,