porous silicon in drug delivery devices and materials多孔硅在药物输送装置和材料.pdfVIP

NIH Public Access Author Manuscript Adv Drug Deliv Rev . Author manuscript; available in PMC 2009 July 15. N Published in final edited form as: I H Adv Drug Deliv Rev . 2008 August 17; 60(11): 1266–1277. doi:10.1016/j.addr.2008.03.017. - P A A u t Porous silicon in drug delivery devices and materials☆ h o r a b b a,* M Emily J. Anglin , Lingyun Cheng , William R. Freeman , and Michael J. Sailor a a n Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, u La Jolla, CA 92093-0358, USA s c r b i Jacobs Retina Center at the Shiley Eye Center, Dept of Ophthalmology, University of California, p t San Diego, La Jolla, CA 92093, USA Abstract Porous Si exhibits a number of properties that make it an attractive material for controlled drug delivery applications: The electrochemical synthesis allows construction of tailored pore sizes and volumes that are controllable from the scale of microns to nanometers; a number of convenient N chemistries exist for the modification of porous Si surfaces that can be used to control the amount, I H identity, and in vivo release rate of drug payloads and the resorption rate of the porous host matrix; - P the material can be used as a template for organic and biopolymers, to prepare composites with a A designed nanostructure; and finally, the optical properties of photonic structures prepared from this A u ma