药学英语期末总结.pdfVIP

药学英语期末复习总结 上册 p69 Text B Lead Compounds 先导化合物 1. 什么是 Lead Compounds? p69 第一段 2. 先导化合物的开发方法和代表药物(p71) Four types i)The first strategy consists of systematic screening of sets of compounds arbitrarily chosen for their diversity , by selected biological assays. 代表药:new antibiotics such as streptomycin ii)The second strategy is based on the modification and improvement of existing active molecules. 代表药:series of lovastatin analogues iii)The third approach resides in the retroactive exploitation of various pieces of biological information that sometimes results from new discoveries made in biology and medicine and sometimes is just the fruits of more or less serendipitous observations. 代表药：nitroglycerol,penicillium notaum,sildenafil iv)The fourth route to new active compounds is a rational design based on the knowledge of the molecular cause of the pathological dysfunction. 代表药：captopril Word captopril n. 卡托普利，甲巯丙脯酸 cimetidine n. 西咪替丁（抗消化性溃疡药） retroactive adj.反动的，追溯的，有追溯力的 nitroglycerol n.硝酸甘油 上册 p94 Biopharmaceutics 生物药剂学 1. BA （生物利用度,bioavailability） The fraction of an administered dose of drug that reaches the systemic circulation in unchanged form is known as the bioavailable dose. The relative amount of an administered dose of a particular drug which reaches the systemic circulation and rate at which this occurs is known as bioavailability of that drug.(p95 第一段第三行至第六行) It should also be noted that in the context of bioavailability ,the term systemic circulation refers primarily to venous blood (excluding 除 了 the hepatic portal blood during the absorption phase) and arterial blood which carries the intact dru