20钙通道阻滞药ppt-钙拮抗药.pptxVIP

Chapter 20  钙通道阻滞药 Calcium channel blockers;Calcium channel blocker ;Calcium is involved in the initiation of smooth muscle, neurotransmitter release, cardiac cell contraction and in the propagation of the cardiac impulse. The calcium channel blockers inhibit the passage of calcium through the voltage gated L-type channels of smooth and cardiac muscle membrane, reduce cytoplasmic free calcium concentration and cause the muscle to relax. ;Type of calcium channel ;L-type calcium channel blocker;Molecular structure of L-type calcium channel ;;钙通道三种状态：激活态、失活态、静息态 ;钙通道阻滞药与激活态（开放态）结合，使通道向