骨髓增生异常综合征PPT演示课件.pptVIP

DNA甲基化的基本作用：抑制基因表达 * DNA+histones = Nucleosome （转录单位） Acetylation/deacetylation乙酰化-去乙酰化 Methylation/demethylation甲基化-去甲基化 Phosphorylation/dephosphorylation磷酸化状态 组蛋白修饰 Histone modifications “histone code” * Epigenetic Alterations m m m m methylation acetylation phosphorylation DNA methylation Histone modifications H3 AC K9 + H4 AC K8 + H3 Ser10P + H3Met K4 + H3 Met K9 – Histone residue Effect * Examples of DNA methylation DNA replication X chromosome inactivation Genomic imprinting(基因组印记): 亲代基因在子代中表达状况取