组织学与胚胎学课件：digestive tract.ppt

Digestive System Digestive tract Digestive gland Digestive tract 1.Organization of digestive tract 肠蠕动动画.avi plicae villi Esophagus Mucosa*epithelium:nonkeratinized striated  squamous epith.* lamina propria* muscularis mucosa: only longitudinal muscle bundles  4.Stomach(fundus) fundic glands Chief or zymogenic cells Parietal or oxyntic cells Mucous neck cells Stem cells endocrine cell microstructure of chief cells In the lower region of glands Cuboidal or low columnar Vacuolated appearance Basally-located nuclei EM of chief cells Microvilli Zymogen granules RER Mitochondria Pyramidal or spherical Strong eosinophilic plasma Centrally-placed nuclei EM of parietal cell Intracellular canaliculi(IC) with few microvilli more SER constitute the tubulovesicles (Resting state) Mucous neck cells Mucous HCO3-Barrier Mucus: Have mucus-containing secretory granules in upper part of cytoplasm. Secrete insoluble mucus containing high content of HCO3-. Function : protects mucosa from being eroded by acid (pH = 0.9~1.5) and enzymes in the lumen of stomach. Summary Master the structure of esophagus, stomach, especially the structure and functions of fundic gland, mucous-HCO3- barrier. Know gastrointestinal five kinds of endocrine cells (EC cells, ECL cells, G cells, I cells and S cells). Understand the general structure of digestive tract. Surface mucous cells * simple columnar epith. * extending into lamina propria, forming the gastric pits * ovoid, basally-located nuclei * mucin granules occupy the supranuclear region with poorly staining in H.E. * prominently tight junction at the cell periphery Function: Produce pepsinogen LM of parietal cell ←→ IC lined by more microvilli, few tubulovesicles (Active state). *secreting hydrochloride acid -providinng acidic condition for activation of the pepsinogen -to kill bacteria *producing intrinsic factor -binding with vitamin B12, aiding its absorption