口腔内科学 口腔内科学、龋病的病因和分类 龋病病因学_.pptVIP

龋病发生中细菌作用的证据Evidences implicating microorganisms  in the etiology of caries 1.Germfree animal do not develop caries 无菌动物不发生龋齿 2.Antibiotics fed to animals are effective in reducing the incidence and severity of caries 抗生素能有效的减少龋病的发生及严重程度 3.Unerupted teeth do not develop caries,yet these same teeth whenexposed to the oral environment and microflora can become carious. 未萌出牙不患龋齿 Oral bacteria can demineralize enamel and dentin in vitro and produce caries-like lesions 从口腔分离出的细菌可引起牙釉质、 牙本质脱矿，产生龋样损害 5. Microorganisms have been histologically demonstrated invading carious enamel and dentin.They can be isolated and cultivated from carious lesions 组织病理学观察在龋损牙釉质、牙本质 内有微生物存在，可以从龋坏中分离和 培养 龋病病因研究史中的重要研究 Microorganisms are important factors for caries occure 细菌在龋病发生中的作用 2. Dental plaque 牙菌斑的研究 3. Aritificial caires model 人工龋模型的建立 牙菌斑生物膜的致病性PATHOGENIC POTENTIAL OF DENTAL PLAQUE BIOFILM  牙菌斑是微生物与环境相互作用形成的微生态系。 菌斑细菌及代谢产物可以引起牙齿和牙周的病理 改变。 Dental plaque is a microbial ecosystem formed by interaction between micro-organisms and their environment.The plaque microflora and products can cause pathological changes in either the teeth or the periodontium. 牙菌斑的致病因子PATHOGENIC CONSTITUENTS OF DENTAL PLAQUE Substances inducing direct tissue damage 引起组织直接损害的物质 organic acids protease 有机酸 蛋白酶 indole collagenase 吲哚 胶原酶 ammonia hyaluronidase 氨 透明质酸酶 hydrogen sulfide neuraminidase 硫化氢 神经氨酸酶