手性亚砜催化pummuer反应.pdfVIP

Pummerer Reactions Using Chiral Sulfoxides 2011,01,29 B4 Misato Fujiwara Sulfoxides and Chiral Sulfoxides - O O 200 °C O- S S+ S+ R1 R2 R1 R2 R2 R1 Inmaculada F.; Noureddine K.*, Chem. Rev. 2003 , 103, 3651−3705 Prepare for Chiral Sulfoxides -O S+ R1 R2 Prepare for Chiral Sulfoxides -O O HO p-Tol S+ O -O S + EtMgI S+ Tol Cl inversion p-Tol Et (R)-1 (S)-2 (–)-menthol 62 % – O O O– + R* nucleophile S HO S+ R* S+ R Cl R O R Nuc chiral alcohols chiral sulfinate esters chiral sulfoxides K. K. Andersen, Tetrahedron Lett. 1962, 3 , 93-95 Herbrandson H. F.; C