结核分枝杆菌生物膜研究进展.pdfVIP

Hans Journal of Medicinal Chemistry 药物化学, 2018, 6(3), 78-84 Published Online August 2018 in Hans. /journal/hjmce /10.12677/hjmce.2018.63011 Advances on Research of Mycobacterium tuberculosis Biofilms Menglan Gan, Renfeng Wang, Zaichang Yang* School of Pharmacy, Guizhou University, Guiyang Guizhou st th nd Received: Aug. 1 , 2018; accepted: Aug. 15 , 2018; published: Aug. 22 , 2018 Abstract Biofilms refer to a microbial community that is surrounded by a self-generated extracellular po- lymer and attached to the cell surface, but the physiology and genetics definition of the M. tuber- culosis biofilm have not yet been described. Because of its unique physiological state, M. tuberculo- sis biofilms limit the therapeutic effect of anti-tuberculosis drugs, prolong the cycle of tuberculosis treatment, and seriously endanger human health. This article reviewed the formation mechanism, structural composition and related functions and quantitative methods of M. tuberculosis biofilms, and discussed the research ideas of using M. tuberculosis biofilms as novel anti-tuberculosis drugs to shorten the treatment of tuberculosis and provide a new direction for improving the therapeu- tic effect of tuberculosis. Keywords Mycobacterium tuberculosis, Biofilms, Tolerance 结核分枝杆菌生物膜研究进展 甘梦兰，王仁凤，杨再昌* 贵州大学药学院，贵州 贵阳 收稿日期：2018年8月1 日；录用日期：2018年8月15 日；发布日期：2018年8月22 日 摘 要 生物膜是指被自我产生的细胞外聚合物包裹，并附着在细胞表面的微生物群落，但结核分枝杆菌生物膜 *通讯作者。 文章引用: 甘梦兰, 王仁凤, 杨再昌. 结核分枝杆菌生物膜研究进展[J]. 药物化学, 2018, 6(3): 78-84. DOI: 10.12677/hjmce.2018.63011 甘梦兰 等 的生理学和遗传学定义至今尚未被描述。抗菌药物耐受性通常与之形成的生物膜有关，结核分枝杆菌生 物膜因其独特的生理状态，限制了抗结核药物的治疗效果，延长了结核病治疗的周期，严重危害人类健 康。该文就