病原生物学英文课件：ENTEROVIRUS GASTROINTESTINAL VIRUSES.pptVIP

Global distribution of rotavirus deaths Non-enveloped virus Double capsid EM appearance of a wheel with radiating spokes Icosahedral symmetry Double stranded (ds) RNA in 11 segments viral attachment protein Pathogenesis and Immunity Transmitted by fecal—oral contamination 10—100 infectious particles Vomiting, diarrhea, fever, and dehydration NSP4 protein – toxin-like manner to promote Ca++ influx into enterocytes. a self-limited disease Disease can be significant?in infants younger than 24 months. Older children, adults reinfected but have mild or no disease. 108-1010 particles/ml feces Labo