病理学与病理生理学总论：GPCR,RTK.pptxVIP

GPCR; Regulation of G-Protein Activity ; Regulation of G-Protein Activity ;RTK;Mechanism of Tyrosine Kinase Receptors ;When the receptors aggregate, the tyrosine kinase domains phosphorylate the C terminal tyrosine residues ;This phosphorylation produces binding sites for proteins with SH2 domains. GRB2 is one of these proteins. GRB2, with SOS bound to it, then binds to the receptor complex. This causes the activation of SOS. ;SOS is a guanyl nucleotide-release protein (GNRP). When this is activated, it causes certain G proteins to release GDP and exchange it for GTP. Ras is one of these prote