病原生物学英文课件：Retrovirus.pptVIP

* Obstacle to HIV Eradication Latent reservoir Loss of CD4 help Latent reservoir Immunodeficiency AIDS Escaping immune control: Latent reservoir (immune-privileged) Mutation druing RT Nef, down regulate the MHC-I. Loss of CD4 T cell help * Laboratory Diagnosis Anti-HIV antibody Routine use for HIV screening Ab develops after 4-6 weeks, remains detectable for life Initial test by ELISA Confirmed by Western blot p24 viral antigen (capsid, CA) for blood screening by ELISA developed before the Ab viral RNA for blood and for babies born by infected moms by RT-PCR * Anti-