临床微生物学概论(二) 细菌的耐药机制及其临床意义.pptVIP

* Bacteria have evolved numerous mechanisms to evade antimicrobial drugs. Chromosomal mutations are an important source of resistance to some antimicrobials. Acquisition of resistance genes or gene clusters, via conjugation, transposition, or transformation, accounts for most antimicrobial resistance among bacterial pathogens. These mechanisms also enhance the possibility of multi-drug resistance. * 染色介导的耐药性特点 * 质粒介导的耐药性特点： 接合型质粒 R， G（－），转移因子RTF，编码性菌毛。 非接合型质粒 r， G（＋） * 接合：转移接合时性菌毛直接沟通耐药菌和敏感菌，R质粒边复制边转移至敏感菌，具非常重要的临床意义。 * * * * * * * * 3-氨基苯硼酸抑制试验（300?g/片）检测KPC型碳青霉烯酶 EDTA协同试验（ 292?g/片