病理学英文课件：Diseases of Cardiovascular system.pptVIP

Pathogenesis: mutation of genes and Ca2+ regulation Cell, Vol. 104, 557–567, 2001. modified. Calcium dysregulation occurs in response to gene mutations that trigger cardiac remodeling. Calcium enters the myocyte through L-type Ca2+ receptors to activate RyR receptors, triggering calcium-induced calcium release (CICR). Increased calcium activates sarcomere contraction. Activation of calciumATPase pump (SERCA), which is regulated by phospholamban (PLN) removes calcium from the cytoplasm and restores sarcoplasmic reticulum levels. The sarcoplasmic reticulum contains calcium binding proteins t