(安博维)与代文的比较ppt参考课件.pptVIP

ARBs降压疗效的荟萃分析 43项研究，11281例 SBP?(mmHg) DBP?(mmHg) Losartan 8.0 5.5 Valsartan 7.5 4.0 厄贝沙坦 10.0 6.5 Telmisartan 9.5 6.0 Candesartan 10.0 6.0 Conlin PR, et al. J Clin Hypertens. 2000;2:253-257 * 安博维?——强效降压的ARB ? BP / Baseline (mm Hg) irbesartan 150 mg valsartan 80 mg Self Measurement (Morning values) ABPM (Trough) Office Measurement (Trough) ADBP ASBP (P0.01) (P0.01) (P0.01) (P0.01) -12 -8 -4 0 (P=0.035) (P0.01) DBP SBP SBP DBP -16 -12 -8 -4 0 Mancia G et al. Blood Press Monit. 2002;7:1-8 *8 week study Δ2.5(66%) Δ3.2(46%) Δ3.2(44%) Δ6.2(62%) -10.5 -16.2 -7.3 -10.0 -6.3 -10.2 -3.8 -7.0 -4.8 -7.5 -6.7 -11.6 Δ1.9(40%) Δ4.1(55%) * 100 90 80 70 60 50 40 30 20 10 0 Patients (%) Treatment Groups N 1156 = 781 96 907 355 646 335 320/CTZ 320 160/HCTZ 160 80 80/12.5 Placebo 7.0 13.1 24.2 4.8 16.7 32.6 3.1 33.3 51.4 17.9 32.8 48.4 25.8 56.4 74.6 22.5 35.7 54.2 45.2 67.1 84.8 2 wk 4 wk 8 wk Weir MR, et al. Am J Hypertens 2007;20:807 缬沙坦剂量对降压疗效的影响 达标率和达标时间 * * 11281例患者荟萃分析证明安博维的降压疗效在ARB中是最好的。 * Mancia et al. compared irbesartan 150 mg vs. valsartan 80 mg monotherapy after 8 weeks, using 3 different techniques: ambulatory blood pressure measurement (ABPM), self and office measurements (426 subjects were randomised to receive either irbesartan or valsartan). The results were consistent, whatever the method used, with a greater overall blood pressure lowering efficacy of irbesartan vs. valsartan over 24 hours. It is to be noted that the differences between the two drugs were even more pronounced in the morning (at trough), which could be related to the longer duration of action of irbesartan. Both treatments were well tolerated. * 代文80MG的效果相当于安慰剂。2007年最新文章。美国高血压杂志。 * 代文80MG的效果相当于安慰剂。2007年最新文章。美国高血压杂志。 * 单药治疗安博维依从性最高。ICE研究 * 7 幻灯片7. 安慰剂对照试验中的药物不良事件 9个安慰剂对照安博维单药治疗4～12周的临床试验，汇总了