ZIF-8纳米颗粒的制备、调控及具体运用-SCI医学论文-基础医学论文-医学论文.docxVIP

ZIF-8纳米颗粒的制备、调控及具体运用-SCI医学论文-基础医学论文-医学论文 ——文章均为WORD文档，下载后可直接编辑使用亦可打印—— 　　摘 要：　沸石咪唑酯骨架材料(Zeolitic Imidazolate Framework-8, ZIF-8)是由锌离子与2-甲基咪唑配位自组装成的多孔结晶材料,其比表面积大、孔隙率高、合成便捷、尺寸可控,在功能物质的包封与输运中具有突出的优势。与此同时,这类材料更具备优异的生物相容性,且其结构在生理条件下具有良好的稳定性,而在酸性条件下解体,对于与恶性肿瘤等多种疾病相关的弱酸性环境具有响应性,是控制药物运输与释放的理想载体,因而在生物医学上有很大的应用潜力。事实上,ZIF-8不但能高效负载阿霉素、5-氟尿嘧啶等小分子化疗药物,而且可以充当抗体、核酸等生物大分子的保护层。ZIF-8的粒径等性能对于相应的生物医学应用非常关键,而如何实现ZIF-8功能性的精准调控将是实现其生物医学应用的重要挑战,基于此,本文就ZIF-8的制备机理、性能调控及其生物医学应用进行综述和展望。 　　关键词：　ZIF-8; 合成机理; 粒径调控; 弱酸性环境敏感; 生物医学应用; 　　Abstract：　Zeolitic imidazolate framework-8(ZIF-8) is a class of porous crystalline materials formed by the self-assembly of zinc ions and 2-methylimidazole. It shows potential advantages in encapsulation and transportation of functional materials owing to its high porosity, large specific surface,convenient synthesis and controllable size. More importantly, ZIF-8 is an ideal carrier for drug delivery and release due to its excellent biocompatibility, stability under physiological conditions and responsiveness to the weak acidic environment associated with malignant tumors and other diseases. In fact, the small molecular drugs(doxorubicin, 5-fluorouracil) and biological macromolecules(antibody, nuclein) have all been loaded into ZIF-8 for chemotherapy, photothermal therapy, photodynamic therapy and biosensing. The particle size of ZIF-8 is very important for biomedical applications, and accurate functional regulation of ZIF-8 is agreat challenge for its biomedical application. Herein, we review the synthesis methods, size-control and biomedicalapplications of ZIF-8. 　　Keyword：　ZIF-8; synthetic mechanism; size control; acidic environmental responsivity; biomedical application; 　　1、 引言 　　金属有机框架材料(Metal-Organic Frameworks, MOFS)是由金属离子或金属簇与多齿有机配体自组装形成的多孔、结晶材料[1]。这种无机-有机杂化材料兼具无机材料和有机材料的优异性能,不仅具有高的比表面积、可调的尺寸和孔隙率,而且载药率高、表面易修饰,因此被广泛应用于催化、气体捕获、传感器、药物递送等领域[2]。 　　沸石咪唑酯骨架材料(ZIF-8)是由锌离子(Zn2+)与2-甲基咪唑(2-MiM)配位而成的一类金属-有机框架,表现出良好的生物相容性和酸性环境敏感性,在生理条件下保持稳定而在酸性条件下解体,是药