解热镇痛药物 .pptxVIP

解热镇痛药物动物的正常体温动物 平均体温体温范围猪39.238.7-39.8乳牛38.638.0-39.3肉牛38.336.7-39.1马37.637.2-38.1绵羊39.138.3-39.9山羊39.138.5-39.7驴37.436.4-38.4狗38.937.9-39.9猫38.638.1-39.2兔39.538.6-40.1正常体温的调节Adjustment of normal temperature发热机制-内生致热原（endogenous pyrogen EP）发热机制-发热中枢调节物质Fever Regulatory mediators of central nervous system血循环中的EP进入脑内，首先作用于体温调节中枢，引起发热中枢介质的释放，继而引起体温调定点上移。发热中枢介质：正调节介质和负调节介质正调节介质：前列腺素E(prostaglandin E, PGE) Na+ ↑ /Ca2+ ↓比值环磷酸腺苷（cAMP）负调节介质：精氨酸加压素（arginine vasopressin, AVP）黑素细胞刺激素（α-melanocyte-stimulating hormone, α-MSH）脂皮质蛋白-1（lipocortin-1）发热机制-发病学Pathogenesis of fever第一环节是外源性的病原体或致炎刺激物或体内某些产物激活产内生致热