盐酸戊乙奎醚高浓度氧雾化吸入对慢性阻塞性肺病的支气管扩张作用.pdfVIP

精品文档 你我共享 摘要】 目的 评价盐酸戊乙奎醚（长托宁）对慢性阻塞性肺病（ COPD ）的支气管扩张作 用。方法 将 92 例 COPD 患者随机分为盐酸戊乙奎醚组 31 例，异丙托溴铵组 34 例，对照 组 27 例 ,两个药物组吸入相应的药物， 3 组均吸入高浓度氧。测定所有患者用药前后第 1 秒 用力呼气量（ FEV1 ）变化。结果 盐酸戊乙奎醚组和异丙托溴铵组 FEV1 较用药前均有显著 增加 (P＜0.05) 。以 FEV1 改善率 15%视为有效，此两组的有效率均高于 80% ，二者比较无 显著差异 (P＞0.05) 。对照组有效率低， 与两个药物组比较差异显著 (P＜0.05)。结论 抗胆碱 能药物通过降低肺动脉压力而明显改善 COPD 患者通气功能。 【关键词】 盐酸戊乙奎醚；异丙托溴铵；慢性阻塞性肺疾病；肺功能 The bronchus expansion function of penehyclidine hydrochloride in patients with COPD YANG Bo ， Lü Xiao Hong ，SHENG Hui. Department of Pulmonary Diseases， the First Hospital of Jilin University,Changchun 130021，Jilin, China 【Abstract 】 Objective To evaluate the efficiency of penehyclidine hydrochloride in patients with chronic obstructive pulmonary disease (COPD). Methods Ninety two patients with COPD were randomly divided into three group ： 31 patientsin penehyclidine hydrochloride, 34 ones in atrovent and 27 ones in control group. The patients in two drug groups inhaled corresponding drugs, all patients in three groups inhaled high concentration oxygen. The forced expiratory volume in one second (FEV1) was measured before and after inhalation. Results FEV1 in two kinds of drug group were both improved after inhalation (P ＜0.05). The efficiency of the two drugs were both higher than 80%, taking the improvement rate15% as effectiveness, but there was no significant difference between both (P0.05). The efficiency of control group was lower, being different from that of the drug groups (P ＜0.05). Conclusions Penehyclidine hydrochloride can obviously improve the lung function of patients with COPD by reducing the pulmonary arterial pressure. 【Key words 】 Penehyclidine hydrochloride ；Atrovent ；C