中国科学院大学-高等有机化学-第七章-第I和II族金属的有机金属化合物-Organometallic Compounds of Group I and II Metals.ppt

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中国科学院大学-高等有机化学-第七章-第I和II族金属的有机金属化合物-Organometallic Compounds of Group I and II Metals.ppt

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8.1.2. Reactions Involving Organocopper Reagents and Intermediates organocuprate reagents is that they are excellent soft nucleophiles, 1. nucleophilic displacements on halides and sulfonates, 2. epoxide ring opening, 3. conjugate additions to -unsaturated carbonyl Compounds 4. additions to alkynes 8.1.2.1. SN 2 and SN 2 Reactions with Halides and Sulfonates Mechanism oxidative addition R2Cu? reductive elimination 8.1.2.1. SN 2 and SN 2 Reactions with Halides and Sulfonates 8.1.2.1. SN 2 and SN 2 Reactions with Halides and Sulfonates 8.1.2.1. SN 2 and SN 2 Reactions with Halides and Sulfonates 8.1.2.2. Opening of Epoxides 8.1.2.2. Opening of Epoxides 8.1.2.3. Conjugate Addition Reactions. 8.1.2.3. Conjugate Addition Reactions. 8.1.2.4. Copper-Catalyzed Reactions 8.1.2.4. Copper-Catalyzed Reactions 8.1.2.5. Mixed Organocopper-Zinc Reagents 8.1.2.6. Carbometallation with Mixed Organocopper Compounds 8.1.2.8. Enantioselective Reactions of Organocopper Reagents. 8.1.2.9. Aryl-Aryl Coupling Using Organocopper Reagents 8.1.2.10. Summary of Synthetic Reactions of Organocopper Reagents and Intermediates 7. Organometallic Compounds of Group I and II Metals Nov. 20th, 2008 Introduction 7.1. Preparation and Properties of Organomagnesium and Organolithium Reagents 7.1.1. Preparation and Properties of Organomagnesium Reagents 7.1.2. Preparation and Properties of Organolithium Compounds 7.1.2.1. Preparation Using Metallic Lithium Preparation Using Metallic Lithium Preparation Using Metallic Lithium Preparation Using Metallic Lithium 7.1.2.3. Preparation by Halogen-Metal Exchange. Halogen-metal exchange 7.1.2.4. Preparation by Metal-Metal Exchange 7.2. Reactions of Organomagnesium and Organolithium Compounds 7.2.1. Reactions with Alkylating Agents 7.2.2. Reactions with Carbonyl Compounds 7.2.2.1. Reactions of Grignard Reagents. 7.2.2.1. Reactions of Grignard Reagents. 7.2.2.1. Reactions of Grignard Reagents. 7.2.2.1. Reactions of Grignard Reagents. 7.2.2.1. Reactions of G