混合细胞白血病英文讲义.docxVIP

1、 Good after noon , every one , today I will in troduce someth ing about acute mixed leukemia. 2、 My comtents include Overview , Clinical feature , Laboratory exam in ati on and diag no sis , Treatme nt,curative effect and prog no ses , Con clusi on. 3、 At first , I will introduce the overview of acute mixed leukemia.what is acute mixed leukemia(MAL)? Huma n acute leukemias (AL) are classified as myeloid or lymphoid accord ing to cytomorphology and the expressi on of leukocyte differe ntiati on an tige ns/CD-markers. However, in the minority of cases leukemic cells express both myeloid and lymphoid an tige ns,these leukemia are defi ned as mixed acute leukemia (MAL) 4、 MAL acco unt for about 2-8% of total AL.It usually happe ns among old pers on s.The pathoge nesis of MAL is not clear. 5、 As the picture shows MAL express both myeloid and lymphoid an tige ns,lt contains three situation , myeloid and T-lymphoid antigens, myeloid and B-lymphoid an tige ns, myeloid and T+B-lymphoid an tige ns, as for T and B Lymphoid an tige ns express respectively or co-expressed in leukemia cells , Which be Classified to MAL by some studies , there is no agreeme nt about whether it be Classified to MAL. 6、 MAL includes three subtypes : biphenotypic acute leukemia (BAL), acute bicl on al leukemia and acute bili neal leukemia 7、 biphe no typic acute leukemia (BAL) refers to acute leukemia with a sin gle populati on of blasts coexpress ing markers of two differe nt lin eages.A nd the co-expressi on of several myeloid and lymphoid an tige ns in the same cells. 8、 This is schematic diagram of biphe no typic acute leukemia (BAL) 9、 acute bili neal leukemia means some leukemia cells express myeloid antigens , others express lymphoid antigens , the two kinds of cells are derived from a sin gle populati on of multipote nt stem cell. the two kinds of leukemia cells exist at the same time, or they don t exist at the sam time, they appear one after ano ther with in 6 mon ths 10、 11、 The two fi