ranitidinehydrochloride盐酸雷尼替丁carmustine卡莫司汀.pptVIP

3). Design(1960---) Design ? ? 60-70 ‘ s β1 -R blocker 、 H 2 -R blocker 70-80 ‘ s ACE inhibitor 、 Calcium blocker Drugs and Targets ? ? ? ? 1.Receptor as drug target; 2.Enzyme as drug target; 3.Ion channel as drug target;; 4.Nucleic acid as drug target; ? Reverse transcriptase Achievements of PRC in Medicinal Chemistry Before 1949 ? 1949---1993: 仿制能力强，创新能力弱 ? 1993/1/1--- 对有关物质实行专利保护：加强创新 1992/1/16 中美政府关于知识产权的谅解备忘录 ? CH 3 H Artemisinin ( 青蒿素 ) O H 3 C O O O H H CH 3 OCH 3 ? 中国科学院上海药物研究所朱大元研究员， 他研制的一类新药蒿甲醚，是国际公认的、由我国 研制的新型抗疟药。 3. Nomenclature of Drug Substances ? Generic Name (INN, 通用名 ) ? Chemical Name ( 化学名 ) ? Trade Name ( 商品名 ) Medicinal Chemistry Purpose ? ? ? ? 1, To familiarize the students with the properties of drugs based on their functional groups ; 2, The molecular mode of action of drugs and the elements of drug design; 3,The chemical nomenclature of important drugs 4, The chemical principles of drugs Grading ? ? ? ? Total points = 100 (middle exams: 30; quizzes: 20; final exam: 50). Middle: Exam s : 8:00 – 10:00 a.m. in Room A101; Quizzes : There will be 2-4 quizzes (10- 20 minutes each) ; Final Exam : BOOKS ? ? ? Text Book : Foye s Principles of Medicinal Chemistry , 5th References : Burger s Medicinal Chemistry 药物化学，主编 尤启冬 Learn ABC of Med. Chem. Chapter 1 Introduction Definition of Medicinal Chemistry ? MC is a chemistry-based discipline , also involving ? aspects of biological, medical and pharmaceutical sciences. It is concerned with the discovery, design, identification and preparation of biologically active compounds; the study of their metabolism; the interpretation of their mode of action at the molecular level and the construction of structure- activity relationships. 1. The Scope and Purpose of MC ? 1) What is medicine? Biologically active compounds are used as