不同人工肝方法治疗乙型肝炎肝衰竭的疗效对比分析.doc

临床经验 CLINICAL PRACTICE 不同人工肝方法治疗乙型肝炎肝衰竭的疗效对比分析 刘凤华，贺玉凯，李庆方，王思奎 2013-07-08 |19 2013-07-08 |19 | ■背景资料 肝衰竭发摘凶 险s进展迅速， 若不进行必要 的干预，生存率 很低.在我国.引 起肝衰竭的病因 主要是乙型肝炎 病毒(hepatitis B virus, HBV),约 占80%-85%?血 浆置换(plasma exchange, PE)与 血浆胆红索吸附 (plasma specific bilirubin adsorp? Cion. PBA)均为有 效的治疗手段，但 各有其局限性,组 合应用人工肝技 术成为必然选择. ■同行评议者 杨江华，副教授， 皖南医学院弋矶 山医院感染科 刘风华，贺玉凯.李庆方?王思奎，聊城市人民医院感染科 东省聊城市252000 刘凤华，主治医师，主耍从书肝衰竭的临床治疗和人工肝方而的 研究. 作者贡献分布：此课题设计由王思奎与刘凤华完成；李庆方折 导：刘凤华与贺玉凯皱贵临床资料收集.数据管理及统计分析； 论文写佶由刘凤华完成；论文审校由王思奎完成. 通讯作者:王思奎，教授，主任医师,252000,山东省聊城市东昌 西路67号，聊城市人民医院感染科. HYPERLINK mailto:wangskl966@wangskl966@ 电话:0635-8272630 收稿日期:2013-04-29修回日期:2013-05-21 接受日期:2013-05-25在线岀版日期:2013-07-08 Comparative study of efficacy of different types of artificial liver treatments in management of hepatitis B-associated liver failure Feng-Hua Liu, Yu-Kai He, Qing-Fang Li, S-Kui Wang Feng-Hua Liu, Yu-Kai He, Qing-Fang Li, S-Kui Wang, Department of Infectious Diseases? Uaocheng Peoples Hospital Liaochcng 252000. Shandong Province, China Correspondence to: Si-Kui Wang, Professor, Chief Physician, Department of Infectious Diseases, Liaocheng People s Hospital, 67 Dongchang West Road, Liaochcng 252000. Shandong Province, China? wnn HYPERLINK mailto:gskl966@gskl966@ Received: 2013-04-29 Revised: 2013-05-21 Accepted: 2013-05-25 Published online: 2013-07-08 Abstract AIM: To investigate the clinical efficacy of plasma exchange (PE), plasma bilirubin adsorption (PBA), and PE combined with PBA in the treatment of hepatitis B-associated liver failure. METHODS: The clinical data for 150 patients with hepatitis B-associated liver failure were retrospectively analyzed. These patients were randomly divided into a PE group, a PBA group, and a PE + PBA group? The volume of plasma consumed once, the effective rate, liver function, alanine aminotransferase (ALT), total bilirubin (TBIL), albumin (ALB), prothrombin time (PT), prothrombin time activity (PTA), creatinine (Cr) and plasma ammonia were recorded both before and