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H21-A5 Vol. 28 No. 5 Replaces H21-A4 Vol. 23 No. 35 Collection, Transport, and Processing of Blood Specimens for Testing Plasma-Based Coagulation Assays and Molecular Hemostasis Assays; Approved Guideline— Fifth Edition This document provides procedures for collecting, transporting, and storing blood; processing blood specimens; storing plasma for coagulation testing; and general recommendations for performing the tests. A guideline for global application developed through the Clinical and Laboratory Standards Institute consensus process. CLINICAL AND LABORATORY STANDARDS INSTITUTE? (Formerly NCCLS) Volume 28 Number 5  H21-A5 ISBN 1-56238-657-3 ISSN 0273-3099 Collection, Transport, and Processing of Blood Specimens for Testing Plasma-Based Coagulation Assays and Molecular Hemostasis Assays; Approved Guideline—Fifth Edition Dorothy M. Adcock, MD Daniel M. Hoefner, MT, PhD Kandice Kottke-Marchant, MD, PhD Richard A. Marlar, PhD Diane I. Szamosi, MA, MT(ASCP), SH(ASCP) David J. Warunek, PhD, MBA Abstract Clinical and Laboratory Standards Institute H21-A5—Collection, Transport, and Processing of Blood Specimens for Testing Plasma-Based Coagulation Assays and Molecular Hemostasis Assays; Approved Guideline—Fifth Edition is an update of the previous edition published in 2003. The guideline provides procedures for the collection, transport, and processing of blood specimens for plasma-based and molecular coagulation testing. Tests of the coagulation system are very sensitive to storage (time and temperature), concentration of anticoagulant, and surface of containers; attention to these parameters is important. H21-A5 is primarily directed toward laboratory and/or clinical personnel responsible for obtaining patient specimens and preparing samples for plasma-based or molecular coagulation testing. Clinical and Laboratory Standards Institute (CLSI). Collection, Transport, and Processing of Blood Specimens for Testing Plasma-Based Coagulation Assays and Molecular Hemostasis