免疫系统复习题b答案.docx

The final examination of medical immunology for seven year students of Grade 2003 2005/12⑹ Paper B I Explain the following items (2 points for each,18 points) McAb Prepared by hybridomas tech nique (1 point) Immunized spleen cells(B) hybride with myeloma cells hybridoma (1 point) MAC C5b6789 complex is known as MAC which leads to formation of a hole in the membrane.(1 point) MAC mediates lysis of target cell.(1 poi nt) Hap te n Substances which can combine with Ab, but cannot induce immune response independently.(1 poi nt) In ano ther word, hapte n only possess immuno reactivity.(1 poi nt) TCR complex a group of membra ne molecules on T cells that can specially bi nd to the an tige n and pass an activati on sig nal into the cells (1 point) con sisti ng of TCR, CD3 and —, (1 point) Hyperse nsitivity a harmful immune response that is heightened reactivity to an antigen is called hypersensitivity, (1 point) which causes tissue injury or functional disorder.(1 point) Cl onal an ergy functional inactivation without cell death(1 point): lack co-stimulatory signal(1 point). Heterophile Ag (forssma n Ag):com mon Ags are shared by differe nt species -no specificity of species (1 point) -Signi fica nee : immuno pathology ,Diag no sis (1 point) 8.ITAM immune receptor tyros in e-based activati on motif (0.5 point)——tran sduce activati on sig nals from TCR(1 point) composed of tyros ine residues separated by around 18 amino acid——whe n an tige n binds,the tyrosine become phosphorylated by the receptor associated tyrosne kinas to transduct activtory sig nal(0.5 point) 9.PRR The receptor on macrophage (1 poi nt)which can recog nize and bi nd specific molecular structure on some pathoge ns,injured or apoptotic cells. (1 point) II. Choose all correct answers (1 point for each, 15 points) No. 1 2 3 4 5 6 7 8 Answer ACD CD AC ACD BCD ABD BD BD No. 9 10 11 12 13 14 15 Answer ABD BCD ABC ABC ABCD ABCD ABC 川。Answer the following questions briefly(5 point for each, 30points) There are two