口腔颌面外科学 口腔颌面外科学 第十二章CleftlipandPalate1_口腔颌面外科学_ff808081-2a596ced-012a-596dd751-2e21.ppt

第十二章 先天性唇腭裂Cleft Lip Cleft Palate戚孟春华北煤炭医学院口腔系 Most common congenital developmental deformities of oral and maxillofacial regionMost common congenital disease in China The deformity will develop with development The deformity will develop with growth The deformity can affected the all organs except eyes in face Incidence CL/P are as fellows: One of every 775 to 1000 whites One of every 1370 to 5000 blacks One of every 479 to 850 Asians One of every 230 to 1000 native Americans CP is as fellows : One of 1500 to 3000 whites One of every 2000 to 5000 blacks One of every 1600 to 4200 Asians One of every 1700 native Americans Cleft lip with palate is 1.5 to 3.0 times as frequent as isolated cleft lip (1995—2000) CL/P are 1.42 per 1000 lives births infants CP is 0.225 per 1000 births infants Contents of this captor section 1: Development of embryo and etiology of Cleft Lip and Cleft palate Section 2: Cleft Lip Section 3: Cleft Palate Section 4: Craniofacial Cleft-horizontal/ oblique/central facial cleft Section 5: Cleft alveolar process Section 1: Embryo development and etiology of CL/P Development of embryo; Formation of facial deformities; Etiology of CL/CP 2. Formation of facial deformities 下唇正中裂或下颌裂 3. Etiology Hereditary factors: Multiple genes Environmental factors Genetic factors Significant increase of CL/P proposition, but isolated CP occurs in a frequency expected in the general population Increase frequency of CP among relative of patients with CP without an increase incidence of CL/P In affected females with CL/P there is a higher frequency of affected offspring than in affected males with CL/P Affected Relatives Predicted Recurrence(%) CL/P CP Environmental factors Nutritional deficiencies Avitaminosis, lack of Ca, P, folic