糖尿病肾病患者25羟维生素D3与视网膜病变的相关性研究.docxVIP

糖尿病肾病患者25羟维生素D3与视网膜病变的相关性研究 [Abstract] Objective：To explore the correlation of 25-hydroxy vitamin D3[25-（OH）D3]with diabetic retinopathy（DR）for diabetic nephropathy.Method：140 diabetic nephropathy patients treated from February 2017 to February 2018 in our hospital were selected and assigned to non-DR group（n=50），non-proliferative DR group（n=47）and proliferative DR group（n=43）according to the situation of DR.46 healthy check-ups were selected as control group.The electrochemiluminescence methods were used to detect 25-（OH）D3 contents.The correlation of 25-（OH）D3 with DR was explored.Result：The high-density lipoprotein cholesterol（HDL-C），total cholesterol（TC）and low-density lipoprotein cholesterol（LDL-C）contents among each groups were not significantly different（P0.05）.25-（OH）D3 contents in the proliferative DR group was lower than those in the non-DR group，the non-proliferative DR group and control group，the differences were statistically significant（P0.05）.glycated albumin（GA）and glycosylated hemoglobin（HbA1c）contents in the proliferative DR group were higher than those in the non-DR group，the non-proliferative DR and the control group，the differences were statistically significant（P0.05）.25-（OH）D3 contents was negatively correlated with DR，and was moderately correlation（r=-0.527，P0.05）.GA and HbA1c contents were positively correlated with DR，and were extremely weakly correlations（r=0.107，0.216，P0.05）.Conclusion：The genesis and pathological courses of DR is affected by 25-（OH）D3.The lower 25-（OH）D3 contents indicate the aggravation of DR，in order to control the illness progression，it is necessary to monitor 25-（OH）D3 contents and supplement Vitamin D. [Key words] Diabetic retinopathy; Diabetic nephropathy; 25-hydroxy vitamin D; Correlation First-author’s address：Shajing People’s Hospital of Baoan Shenzhen，Shenzhen *****，China doi：10.3969/j.issn.1674-4985.2019.14.029 糖尿病具有多种并发症，其中以肾病最为常见，该疾病与肾小管、肾小球病变有直接联系，会造成人体出现蛋白尿。糖尿病肾病会从微量蛋白尿逐渐发展成临床蛋白尿，直至出现终末