杂环化合物及其应用-小环的合成解析.pptVIP

2021/2/11 * 3. 环重排制备 例1: 例2: OH 2021/2/11 * 第三节 五元杂环化合物的合成 1. 四氢呋喃的合成 Synlett, 2006, 1440-1442. A）最常用的合成四氢呋喃呋喃的方法是催化氢化: B）1,4-二醇的脱水关环: Synlett, 2006, 1756-1758 2021/2/11 * C）γ,δ-不饱和醇的关环: Am. Chem. Soc., 2004, 126, 9536-9537. Org. Lett., 2005, 7, 4553-4556 J. Am. Chem. Soc., 2006, 128, 9066-9073 D）其它方法: Syn addition See that there are two regioisomers possible, so regioselectivity is an added issue Ideally would want to be able to control regio stereo select by using different “recipies” A nitrogen source is also oxidant Precursor to Taxol side chain JOKE QUESTION Nitrogen source also ac