抗肿瘤药阿扎胞苷.docxVIP

抗肿瘤药阿扎胞苷 Antineoplastic agent azacitidine Zhang Qing-wen (Shanghai Institute of Pharmaceutical Industry ， Shanghai 200437 ， China ) Azacitidine is a new epigenetic antineoplastic agent and is the only agent which has been clinically demonstrated to be able to extent a significant overall survival for the patients with higher-risk myelodysplastic syndromes and has also been approved by both the USFDAand the European Commission. S azacitidine ； myelodysplastic syndromes ； acute myeloid leukemia 阿扎胞苷( azacitidine )最早由捷克斯洛伐克科学家 Piskala和Sorm合成[1]，后来又从拉达克链轮丝菌 (Streptoverticillium ladakanus )发酵液中被分离得